Midi

DHEA/Estradiol

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

cream bottle

Compounded Formulations:

DHEA 5mg + Estradiol 0.1mg/ml VaginalCream

FDA Approval:

Estradiol

  • Vulvar and vaginal atrophy associated with menopause

DHEA

  • Dyspareunia secondary to vulvar and vaginal atrophy due to menopause

Mechanism of Action:

Estradiol

  • Local estrogens have been shown to reduce vaginal pH as well as mature the vaginal and urethral mucosa to improve vaginal dryness and mucosal atrophy.

DHEA

  • DHEA itself a natural hormone that helps produce both testosterone and estrogen, both of which help with collagen and elasticity. DHEA is often used as a testosterone booster as well.

Benefits:

Vaginal Dryness

  • Topical estrogen may improve vaginal lubrication through decreased vaginal pH, increased blood flow, and lubrication.Subsequently women have reported decreased vaginal irritation leading to increased sexual desire and quality of life.

Libido

  • Topical estrogen and DHEA improves vaginal health. Additionally the DHEA is a precursor to testosterone, which may improve sexual health.

Suggested Dosing:

  • Apply 1 gram to labia, vulva and vaginal vestibule.

Storage/Stability:

  • Store in the original container at 68°F to 77° away from heat, moisture, and light.

Breastfeeding:

  • Estrogens are present in breastmilk and have been shown to decrease the quantity and quality of human milk.

Drug interactions:

  • Anastrozole (Estradiol)
  • Cosyntropin (Estradiol)
  • Exemestane (Estradiol)
  • Fexinidazole (Estradiol)
  • Fezolinetant (Estradiol)
  • FusidicAcid (Estradiol)
  • Growth Hormone Analogs (Estradiol)
  • Hemin (Estradiol)
  • Indium 111 Capromab Pendetide (Estradiol)
  • Metyrapone (Estradiol)
  • Ospemifene (Estradiol)
  • Raloxifene (Estradiol)
  • Tizanidine (Estradiol)
  • Tranexamic Acid (Estradiol)