Dark Spot: Hydroquinone Cream
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. The following information has been provided by the package inserts.
Compounded Formulations:
Hydroquinone Ascorbic Acid Niacinamide Cream
FDA Approval:
- Topical skin lightening agent (Hydroquinone)
- The FDA does not currently require approval for vitamins and/or supplements (Ascorbic Acid and Niacinamide)
Mechanism of Action:
- Hydroquinone – reduces melanin pigment production through inhibition of the tyrosinase enzyme, which is involved in the initial step of the melanin pigment biosynthesis pathway.
- Ascorbic Acid – assists in lightening dark patches on skin
- Niacinamide – blocks enzymes associated with skin discoloration
Benefits:
- Hydroquinone combination therapies may significantly decrease lesion size, pigmentation, and disease severity in those with post inflammatory hyperpigmentation.
- Over a 3-month treatment period, 70% of melasma patients experience reduced or cleared pigmentation.
- May improve skin texture
Warning / Contraindications:
- Avoid sun exposure or use sun protection
Suggested Dosing:
- Melasma - Apply one pump of cream to the affected area (face) at night time.
Administration:
- Topical
- Apply to clean and dry affected area
- Use medication for 4 months consecutively, and take 1 month off period to risk of rebound hyperpigmentation
Storage/Stability:
- Room Temperature
- Protect from moisture and excessive heat
- Beyond Use Date: 6 months (180 days)
Pregnancy:
- Not recommended during pregnancy
Breastfeeding:
- It is not known if present in breast milk, use with caution
Side Effects:
- Abdominal pain
- Dry mouth