Tretinoin Active Renewal Cream

Tretinoin is a prescription-strength retinoid that speeds skin cell renewal, boosts collagen, smooths texture, and helps fade fine lines and dark spots. Proven in decades of use by skincare experts, our clinicians choose it to support midlife skin changes like slower cell turnover, dryness, and collagen loss.

Important: Tretinoin increases sun sensitivity, so daily sunscreen is key for protecting new skin cells and getting the best results.

As estrogen and progesterone decline, cell renewal slows, collagen breaks down faster, and the skin barrier thins. Midi’s Tretinoin Active Renewal Cream is designed to support these hormonal changes, boosting cell turnover while hydrating and strengthening a smoother, healthier-looking complexion.

During weeks 1-4, increased cell turnover may cause mild dryness or minor breakouts. By weeks 6-8, skin typically appears brighter and feels smoother. After 12 weeks or more, dark spots begin to fade and fine lines soften, revealing a more even, refreshed complexion.

Yes—sun protection becomes even more important when using tretinoin. Tretinoin speeds up skin cell renewal, which means newer, more delicate skin is exposed at the surface. Using a daily broad-spectrum sunscreen helps protect those new skin cells, reduce irritation, and support smoother, more even results over time.