July 16, 2024
(updated on Aug 12, 2026)

Weird Perimenopause Symptoms: 30 Signs to Know

Author:
Redeat GebeyehuRedeat Gebeyehu
Medically reviewed by:
Image of Rebecca Yee, MDRebecca Yee, MD
A close-up view of a woman holding onto her back. She is dealing with itchy skin, a weird perimenopause symptom.
The Big Picture

During perimenopause, you might expect changes like hot flashes or irregular periods, but the transition can also bring some seriously weird perimenopause symptoms that affect your hair, skin, brain, and other parts of your body. As estrogen and other reproductive hormones fluctuate, you might notice surprising shifts, from itchy skin to sensitive teeth. The good news? You don't have to figure it all out on your own. A menopause specialist, like a Midi clinician, can help you understand what's happening, rule out other possible causes, and create a personalized plan to manage your symptoms, no matter how unexpected.

When you’re in perimenopause, symptoms like hot flashes, night sweats, and irregular periods seem to get all the attention. But seemingly weird perimenopause symptoms like allergies, dry mouth, and body odor changes can show up, too.

During perimenopause (which is the natural, often years-long transition before menopause), estrogen and other reproductive hormones fluctuate and decline. This transition usually begins in your mid-40s, though it can start earlier or later, and ends when you’ve gone 12 consecutive months without a period. As your hormone levels change, they can affect several different parts of your body, leading to a wide range of lesser-known symptoms.

You might be caught off guard by unexpected changes, but that doesn’t mean you’re imagining them. When we stay in the dark about unusual perimenopause symptoms—which are more common than you might think—they can go undiagnosed, causing frustration, unnecessary days of feeling “off,” or worse. The more you understand what's happening, the easier it is to recognize changes and get the care you need.

As you explore the 30 (yes, 30!) symptoms below, remember that you're not alone—and that many can improve with the right care and support. A Midi clinician can help you decode what's behind your symptoms and create a treatment plan that’s best for you. That's important because not every new or unusual symptom is caused by perimenopause.

IN THIS ARTICLE

What to Know About Weird Perimenopause Symptoms

Perimenopause symptoms can affect much more than your reproductive system. While many women expect more common symptoms like hot flashes or weight gain, fluctuating hormones during the menopause transition can also show up in surprising ways, affecting everything from your skin and gut to your brain and heart. 

That's because estrogen receptors aren't just in your reproductive organs—they're found throughout your body, including your skin, gut, brain, and heart. That's part of why fluctuating hormone levels during perimenopause can affect so many different organs and systems, not just your period.

We’ll cover some of these weird perimenopause symptoms (and more) below, including:

  • Tingling or itchy skin 
  • Electric shocks 
  • Burning mouth
  • Digestive changes 
  • Heart palpitations
  • Body odor changes 
  • Dizziness
  • New allergies

Many of these symptoms are linked to fluctuating estrogen and progesterone, but not every new, unusual, or persistent symptom is caused by perimenopause. 

Tracking when symptoms occur and how they change can help. You can bring your tracker to a healthcare professional, like a Midi clinician, who can help you figure out what’s going on and how to find relief. 

A chart about 30 Surprising Symptoms of Perimenopause. There is a visual of a woman with symptom labels pointing to her, from tingling skin to brittle nails.

Weird Perimenopause Symptoms by Body System

Symptom Body System What It Can Feel Like Why It May Happen When to Ask a Clinician

Breast soreness

Muscles, joints, and soft tissues

Tender, swollen, or painful breasts

Fluctuating estrogen and progesterone can affect breast tissue

Pain is severe, persistent, one-sided, or comes with a new lump

Itchy skin

Hair, skin, and nails

Dry or itchy skin with or without a rash

Fluctuating estrogen can make skin thinner and drier

Itching is severe, persistent, widespread, or associated with rash

Tingling skin or "pins and needles"

Nerves and sensations

Tingling, prickling, or numbness, often in the arms, hands, legs, or feet

Hormone fluctuations may affect nerve signaling

Symptoms are persistent, worsening, or affect one side or a specific area of the body

Electric shock sensations

Nerves and sensations

Brief zap-like feelings in the head or body

Hormone fluctuations may affect the nervous system

Symptoms are frequent, severe, or occur with other neurological symptoms

Tinnitus

Nerves and sensations

Ringing, buzzing, or humming in the ears

Fluctuating hormones may affect the auditory system

Symptoms are persistent, worsening, or occur with hearing loss

Sensitive teeth, sore gums, and other dental changes

Mouth, teeth, and eyes

Sensitive teeth, sore or bleeding gums, or other oral changes

Hormonal changes can affect the gums and oral tissues

Severe or ongoing pain, swollen gums, persistent bleeding gums, or other signs of infection

Dry mouth

Mouth, teeth, and eyes

Sticky or dry mouth, increased thirst, or trouble swallowing

Lower estrogen can reduce saliva production

Symptoms are persistent or interfere with chewing or swallowing

Burning mouth

Mouth, teeth, and eyes

Metallic taste, burning, tingling, or scalding feeling in the tongue, lips, or mouth

Hormone changes may affect oral tissues and nerves

Symptoms interfere with eating, drinking, or daily life

Altered taste

Mouth, teeth, and eyes

Foods taste different or less flavorful

Hormonal changes may affect taste receptors

Symptoms are persistent or interfere with eating

Dry eyes

Mouth, teeth, and eyes

Gritty, irritated, or watery eyes and temporarily blurred vision

Hormone changes can reduce tear production

Ongoing symptoms affect vision or don't improve with eye drops

Joint pain

Muscles, joints, and soft tissues

Achy, stiff, or painful joints

Declining estrogen can affect joints and connective tissue health

Pain is persistent, severe, or accompanied by swelling or redness

Muscle aches

Muscles, joints, and soft tissues

Muscle pain, soreness, or stiffness

Hormone changes may affect muscles

Severe or persistent pain or weakness

Hair thinning and texture changes

Hair, skin, and nails

Increased hair shedding, thinning, or texture changes

Hormone shifts can affect the hair growth cycle

Rapid, patchy, or concerning hair loss

Chin hair or other facial hair growth

Hair, skin, and nails

New facial hair, especially on the chin

Hormone changes shift the balance between estrogen and androgens

Facial hair growth is sudden, hard to manage, or accompanied by symptoms such as acne or irregular periods

Brittle nails

Hair, skin, and nails

Nails that peel, split, or break easily

Fluctuating hormones may affect nail strength

Severe or painful nail changes or signs of infection like redness or pus

Bloating

Gut and digestion

Feeling unusual fullness or pressure in the stomach

Hormone fluctuations can slow digestion and affect fluid balance

Symptoms are persistent, severe, or accompanied by unexplained weight loss

Constipation, diarrhea, and other digestive changes

Gut and digestion

Constipation, gas, loose stools, acid reflux, or changes in bowel habits

Hormone fluctuations can slow digestion

Symptoms are persistent, severe, or include blood in the stool

Heart palpitations

Heart and circulation

Racing, pounding, fluttering, or skipped heartbeats

Hormone fluctuations can affect heart rhythm and blood vessels

Symptoms occur with chest pain, fainting, or shortness of breath

Dizziness

Heart and circulation

Feeling a spinning sensation, lightheaded, or off balance

Fluctuating hormones may affect blood vessels, blood pressure, or the inner ear

Symptoms are frequent, severe, or accompanied by fainting

Headaches or migraines

Nerves and sensations

Throbbing or pulsing head pain with sensitivity to light or sound

Hormone fluctuations may trigger headaches or migraines

New, sudden, or severe headaches

New or worsening allergies

Immune system

New or worsening allergy symptoms like sneezing, itching, or watery eyes

Hormone changes may influence immune and inflammatory responses

Ongoing symptoms don't improve with OTC medication or trouble breathing

Incontinence, urinary urgency, and other bladder changes

Bladder and sexual health

Frequent or sudden, hard-to-control urge to urinate, urinary leakage, or recurrent UTIs

Lower estrogen can affect the bladder and pelvic tissues

Symptoms cause pain, affect daily life, or occur with pain, blood in the urine, or recurrent infections

Vaginal dryness, itching, or irritation

Bladder and sexual health

Dryness, itching, irritation, or painful sex

Lower estrogen can make vaginal tissue thinner and drier

Symptoms affect comfort or intimacy

Lower libido

Bladder and sexual health

Less interest in sex

Hormonal, physical, and emotional changes can affect sex drive

Symptoms are concerning or affect your relationships

Body odor changes

Hair, skin, and nails

New or worsening body odor

Hormone shifts may cause increased sweating or bacteria on the skin

Persistent or bothersome symptoms are hard to manage

Fatigue

Brain, mood, and energy

Feeling unusually tired or lacking energy throughout the day

Hormone fluctuations may trigger night sweats, increase stress, and cause other changes that can affect sleep quality and energy levels

Persistent or severe fatigue interferes with daily activities

Brain fog

Brain, mood, and energy

Trouble concentrating, remembering, or finding words

Hormone fluctuations may affect brain function and sleep

Persistent or worsening symptoms interfere with work or daily functioning

Mood swings

Brain, mood, and energy

Sudden or unpredictable mood changes

Fluctuating estrogen can affect brain chemicals involved in mood

Persistent mood changes affect quality of life

Anxiety and depression

Brain, mood, and energy

Persistent sadness, loss of interest, excessive worry, restlessness, irritability, or a racing heart

Fluctuating hormones influence stress and mood regulation

Symptoms last more than two weeks, interfere with daily life, or include thoughts of self-harm

Panic attacks

Brain, mood, and energy

Sudden episodes of intense fear with a racing heart, shortness of breath, or dizziness

Hormone fluctuations may contribute to changes in the body's stress response

Recurrent attacks, worsening symptoms, or thoughts of self-harm

Keep in mind: Many of these symptoms can also be caused by other health conditions, such as thyroid disorders, anemia, or autoimmune diseases. Medications, or lifestyle factors can also play a role. A healthcare professional can help determine whether your symptoms are related to perimenopause or another underlying cause.

Below, read more about each of these surprising or weird perimenopause symptoms you might not have seen coming—and how to find relief from each.

1. Breast Soreness

Maybe you're used to breast tenderness around your period. But if your breasts suddenly feel more sore than usual during perimenopause, fluctuating hormones could be the reason. As estrogen and progesterone rise and fall more unpredictably during the menopause transition, they can affect breast tissue. You may have pain, tenderness, heaviness, swelling, or even a burning sensation in one or both breasts. (This feeling often lessens in late perimenopause and after menopause, but if you start hormone therapy, it may increase tenderness again as your body adjusts.)

What helps: 

  • Wearing a supportive, well-fitting bra 
  • Taking over-the-counter (OTC) pain relievers or supplements like vitamin E 
  • Using a warm or cool compress, depending on what feels best

2. Itchy Skin 

When it comes to weird perimenopause symptoms, itchy ears have gotten a lot of attention lately. But hormone changes can trigger itchiness almost anywhere on your body. Some women may feel unusual itchiness during the menopause transition, and it can strike the face, back, chest, and genital area.

Why does this happen? As estrogen decreases, your skin loses collagen and moisture, making it thinner, drier, and more sensitive. This can lead to several skin changes, from itchiness to acne and rosacea-like flares.

Dry skin may continue after menopause, but a consistent skincare routine can help ease symptoms and protect your skin barrier. 

What helps: 

  • Applying topical anti-itch creams when appropriate
  • Using a gentle cleanser and moisturizing once or twice a day, especially after bathing 
  • Wearing sunscreen with SPF 30 or higher every day  
  • Avoiding long or hot showers and harsh skincare products that can make itchiness or dryness worse 

3. Tingling Skin

You know that tingling, pins and needles feeling that happens when your foot falls asleep? Well, you might notice more of that strange tingling sensation, numbness that comes and goes, or even a crawling sensation on the skin during perimenopause. Also known as paresthesia, the odd feeling is usually brief and affects the hands, feet, arms, and legs. 

Experts think fluctuating estrogen may affect nerve function, which can make these sensations more likely.  

What helps:

  • Moving your body or stretching to restore blood flow 
  • Prioritizing healthy sleep, a balanced diet, and regular exercise
  • Seeking prompt medical care if tingling is sudden, affects one side of your body, or occurs with weakness, chest pain, or trouble speaking
@midihealth Another day, another (really weird 🐞) perimenopause symptom. #menopause #perimenopause #hormones ♬ original sound - Midi Health

4. Electric Shock Sensations 

Ever feel a sudden, sharp zap that seems to come out of nowhere? It sounds strange, but some women experience brief electric shock sensations during perimenopause that feel like a quick jolt or a rubber band snapping against the skin.

Shifting estrogen may alter nerve function and sensory processing in the brain. The result might be brief brain or body zaps, often just before a hot flash. Stress, anxiety, and poor sleep can also make those random zaps feel more noticeable. 

What helps: 

  • Prioritizing healthy sleep 
  • Managing stress with mindfulness, meditation, or other healthy outlets 
  • Cutting back on alcohol, a potential trigger

5. Tinnitus 

Noticing a ringing, buzzing, hissing, or whooshing sound in one or both ears? Tinnitus is one of those annoying perimenopause symptoms that can happen during the menopause transition. Experts aren't exactly sure why, but they think shifting estrogen levels may change the way the inner ear and brain process sound.

And as if that wasn't enough, fatigue, stress, anxiety, and poor sleep—all common midlife complaints—can make it feel worse or more noticeable.

What helps:

  • Protecting your hearing by avoiding loud noises or wearing earplugs
  • Managing stress and prioritizing good sleep
  • Using white noise or sound therapy to help mask symptoms
  • Trying cognitive behavior therapy 
  • Talking with a healthcare professional about persistent or worsening symptoms 

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6. Sensitive Teeth, Sore Gums, and Other Dental Changes

Your next dental appointment could come with a few surprises in midlife. During perimenopause, fluctuating hormones may contribute to oral health changes like increased tooth sensitivity and sore or bleeding gums. 

That’s likely because declining estrogen can affect your teeth, gums, saliva, and jawbone, increasing the risk of problems like dry mouth, gum disease, tooth decay, and tooth loss.

But menopause isn't the only factor that can contribute to these changes, so regular dental checkups are important.

What helps:

  • Brushing twice a day and flossing daily
  • Keeping up with regular dental checkups and cleanings
  • Using a soft-bristled toothbrush if your teeth or gums are sensitive

7. Dry Mouth

Dry mouth causes a sticky or dry feeling that can make it harder to chew or swallow. And it’s actually pretty common during perimenopause and menopause. Researchers think it may be because estrogen and progesterone help support salivary glands and the tissues lining the mouth. 

Hormone changes during perimenopause may reduce saliva production. But certain medications and health conditions like diabetes can also cause dry mouth. Because saliva helps protect your teeth, gums, and other oral tissues, treating persistent dry mouth can improve both comfort and oral health.

What helps:

  • Drinking water to stay hydrated throughout the day
  • Chewing sugar-free gum to help stimulate saliva
  • OTC saliva substitutes that come as liquids, sprays, and lozenges 
  • Practicing good oral hygiene, like brushing with a fluoride toothpaste twice daily, to prevent cavities 

8. Burning Mouth 

Imagine the sensation you get when you take a sip of hot coffee—it's pretty similar to what a burning mouth or burning tongue feels like. The scalding or tingling sensation may affect the gums, tongue, cheeks, and lips. It can also cause numbness and a bitter or metallic taste in your mouth. 

Burning mouth syndrome is more common in midlife and postmenopausal women, but experts aren't exactly sure why. Hormone changes may play a role, but several other conditions can cause similar symptoms, so it's important to get evaluated if symptoms don't go away.

What helps:

  • Staying hydrated throughout the day
  • Avoiding spicy or acidic foods if they make symptoms worse
  • Seeing a healthcare professional or dentist if symptoms persist or keep coming back

Annotated body listing surprising symptoms

9. Altered Taste

Some women notice changes in taste during perimenopause, such as foods tasting less sweet or more bitter than usual, foods having a metallic taste, and new food sensitivities or aversions. This weird perimenopause symptom may happen because fluctuating hormones can affect taste perception. And it can change your eating habits, appetite, and cravings

But altered taste is likely caused by multiple factors. Dry mouth, for example, may affect how food tastes. Other conditions and medications can also be a factor.

What helps:

  • Maintaining good oral hygiene, like regular brushing and flossing 
  • Staying hydrated and treating dry mouth, if it's contributing
  • Experimenting with herbs, spices, or other seasonings to improve flavor
  • Talking with a healthcare professional if taste changes are persistent or affect eating

10. Dry Eyes

Dry eyes are more common in women than men, and they're especially common during the menopause transition. In one study, nearly two-thirds of women between the ages of 41 and 60 reported dry eye symptoms such as gritty or irritated eyes, light sensitivity, and blurred vision. Another study found that nearly 80% of postmenopausal women reported dry eye symptoms.

So, what does menopause have to do with your eyes? Hormone shifts may reduce tear production, but aging, prolonged screen time, certain medical conditions, and some medications can also increase the risk or worsen symptoms.

What helps:

  • Using artificial tears or lubricating eye drops
  • Turning on a humidifier to add moisture to the air
  • Taking regular breaks from screens and blinking more often
  • Getting annual eye exams 
  • Talking with an eye care professional if symptoms are persistent or severe

11. Joint Pain 

Menopause and joint pain go hand-in-hand for many women. Estrogen helps protect your bones and joints by supporting the tissues around them and regulating inflammation. As it shifts during perimenopause, you might have hand or finger aches, hip or knee pain, neck or shoulder tension, and morning stiffness.

What helps: 

  • Strength training to support your joints 
  • Gentle stretching and mobility work, especially in the morning 
  • Physical therapy, when needed 
  • Talking with a healthcare professional if a joint is red, hot, or swollen

12. Muscle Aches 

Hormone highs and lows during perimenopause may also leave your muscles feeling sore, tight, or more tender than usual. Studies suggest that nearly 71% of perimenopausal women experience joint or muscle pain. It might come with lingering soreness after workouts or extra tension in your neck, shoulders, or back. Aging, stress, poor sleep, and changes in activity level can also play a role. 

What helps: 

  • Eating a balanced diet with enough protein to support muscle health 
  • Staying active while giving your body time to recover after exercise 
  • Prioritizing good sleep to support muscle recovery

13. Hair Thinning and Texture Changes 

Your hair might not look or feel the same during perimenopause. Noticeable hair loss—including thinning hair in certain areas, slower hair growth, and hair texture changes—has been linked to the menopause transition. Estrogen tends to drop faster than androgens (often called male hormones). That can mean less hair on the head along with fuzzy hair in new areas (more on that next).

What helps: 

  • Eating a well-balanced diet rich in vitamins and nutrients 
  • Reducing stress and finding healthy coping mechanisms 
  • Asking a clinician about prescription medications such as minoxidil and finasteride 

14. Chin Hair or Other Facial Hair 

If you've started spotting a few stubborn chin hairs during perimenopause, you're not alone. One study found that nearly 40% of women reported increased facial hair after menopause, with the chin being the most common spot. As hormones shift throughout the menopause transition, the balance between estrogen and androgens changes. That can contribute to new facial hair on the chin, upper lip, or jawline. 

What helps:

  • Tweezing, shaving, waxing, or threading unwanted hair
  • Trying laser hair removal for longer-lasting results 
  • Using prescription treatments such as spironolactone or finasteride 

15. Brittle Nails 

Weak or brittle nails are another common change during the menopause transition. A combination of hormone shifts and natural age-related changes can slow nail growth and make your nails more prone to splitting, peeling, flaking, or cracking. That might explain why brittle nails are especially common in women over 50.

What helps: 

  • Staying hydrated and eating a balanced diet 
  • Moisturizing your hands, nails, and cuticles regularly
  • Limiting exposure to harsh chemicals like acetone-based nail polish removers
  • Avoiding smoking

16. Bloating 

That unpleasant feeling of fullness or tightness in your abdomen could be hormone-related, particularly during perimenopause. Hormonal highs and lows may contribute to water retention and digestive changes that can leave you feeling bloated and uncomfortable. 

Bloating may come and go throughout the menopause transition and often improves when hormones level out after menopause. 

What helps: 

  • Staying hydrated
  • Eating smaller, balanced meals
  • Limiting foods that trigger your symptoms
  • Exercising regularly
  • Taking steps to manage stress

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17. Constipation, Diarrhea, and Other Digestive Changes

Hormonal ups and downs during perimenopause can slow or speed up digestion, make your stomach more sensitive, and change the balance of bacteria in your gut. 

The result? Many women deal with gastrointestinal issues throughout the menopause journey, including constipation, diarrhea, gas, acid reflux, and abdominal discomfort. Symptoms may also worsen if you already have a digestive condition, such as irritable bowel syndrome (IBS).

What helps:

  • Gradually increasing your fiber intake and staying hydrated
  • Eating a balanced diet rich in fruits, vegetables, and other fiber-rich foods
  • Staying physically active 
  • Talking to a healthcare professional if you have blood in your stool, unexplained weight loss, severe abdominal pain, or persistent digestive symptoms

18. Heart Palpitations 

Studies suggest that up to 42% of perimenopausal women and up to 54% of postmenopausal women experience heart palpitations, and they can be disconcerting, to say the least. Described as a racing heart, fluttering, pounding, or skipped beats, palpitations can occur with dizziness.

Estrogen helps protect the heart and blood vessels, so when it declines, changes in the cardiovascular system may contribute to heart palpitations. Hot flashes, anxiety, caffeine, alcohol, poor sleep, and thyroid conditions can also trigger them. 

If your palpitations are new, severe, frequent, last more than 5 minutes, or occur with chest pain, shortness of breath, or feeling faint, talk with a healthcare professional right away.

What helps: 

  • Tracking when your palpitations happen and looking for possible triggers
  • Limiting triggers, like caffeine or alcohol, and avoiding smoking 
  • Eating a heart-healthy diet, staying hydrated, prioritizing good sleep, and exercising regularly if it doesn’t trigger symptoms
  • Asking a healthcare professional about hormone therapy if you suspect hormone changes are contributing to your symptoms 

Midi symptom checklist

19. Dizziness

About 36% of women experience dizziness at least once a week during perimenopause or after menopause. Hormone changes may affect the body's balance, nervous, and cardiovascular systems, which may contribute to lightheadedness, dizziness, or a vertigo-like sensation in some women. Hot flashes, night sweats, and anxiety can also make dizziness feel worse.

What helps:

  • Staying hydrated
  • Taking anti-dizziness or anti-anxiety medications
  • Asking a healthcare professional about hormone therapy if you have other menopause symptoms

20. Headaches or Migraines 

A steady estrogen level supports neurological function, which is why some women experience headaches during their menstrual cycles, when estrogen dips. Similarly, erratic hormones during perimenopause may trigger headaches or migraines

Research suggests that migraines may become more frequent, severe, or harder to predict during this transition. Common symptoms include throbbing head pain, nausea, and sensitivity to light or sound.

The good news? Many women see some improvement after menopause.

What helps: 

  • Keeping a headache symptom tracker to identify patterns and triggers
  • Staying hydrated and maintaining a regular sleep schedule
  • Getting regular physical activity
  • Taking medications or supplements recommended by a healthcare professional

21. New or Worsening Allergies

Do foods and environments that never bothered you in the past now trigger sneezes, hives, or other allergy symptoms? As the body undergoes hormone changes during menopause, the immune system may respond differently, making some women more sensitive to allergens. That can lead to new allergies or make existing ones worse.

Those immune system changes may also affect conditions like asthma. In one study, perimenopausal women had more than twice the odds of developing asthma as non-menopausal women.

What helps: 

  • Knowing your triggers and reducing exposure 
  • Taking antihistamines, such as cetirizine (Zyrtec) or loratadine (Claritin)
  • Using nasal saline sprays or rinses for nasal allergy symptoms

22. Urinary Urgency or Leakage  

More than 50% of postmenopausal women experience urinary incontinence, whether it's leaking urine when you sneeze or laugh or not making it to the bathroom in time. You might also find yourself dealing with urinary urgency that makes you rush to the bathroom more often, waking up to pee in the middle of the night, or getting recurrent urinary tract infections (UTIs).

As estrogen lowers, the tissues that support the bladder and urethra become thinner and less flexible, and the pelvic floor muscles can weaken, making these symptoms more common. 

What helps: 

  • Strengthening your pelvic floor with Kegels or pelvic floor physical therapy 
  • Cutting back on caffeine and alcohol, which can irritate the bladder 
  • Talking with a healthcare professional about hormone therapy, including vaginal estrogen

23. Vaginal Dryness, Itching, and Pain During Sex 

While vaginal dryness is one of the better-known symptoms of perimenopause, it may also come with vulvar itching, irritation, and burning with sex or pain during sex that people don't always realize can be hormone-related.

When estrogen declines, vaginal tissues become thinner, drier, and less elastic, making them more prone to dryness, irritation, and discomfort. Vaginal and urinary symptoms may start during perimenopause and continue after menopause without treatment.

What helps: 

  • Using OTC anti-itch creams or sitz baths to help soothe itching
  • Trying OTC vaginal moisturizers and lubricants to improve comfort during sex
  • Talking with a healthcare professional about vaginal estrogen or other prescription treatments to help restore moisture 

24. Lower Libido 

When you're dealing with bothersome perimenopause symptoms like vaginal dryness, itching, or painful sex, it may be less surprising if your libido takes a dive. And you're not alone—about 38% of women in the U.S. report low sexual desire, according to a comprehensive study

As estrogen fluctuates during perimenopause (and testosterone also gradually declines with age), sexual desire may change. Other perimenopause symptoms—including hot flashes, poor sleep, and fatigue—can also make it harder to get in the mood.

That said, a low libido isn't always related to perimenopause. Stress, relationship problems, certain medications, and other health conditions can also play a role.

What helps: 

  • Using OTC vaginal moisturizers or lubricants
  • Trying a vaginal estrogen cream, vaginal ring, or vaginal DHEA/estradiol
  • Talking with a healthcare professional about systemic menopause hormone therapy, such as a pill, patch, or spray, when appropriate 
  • Asking a healthcare professional about off-label prescription testosterone therapy 
  • Making lifestyle changes like regular exercise, a balanced diet, and stress management

25. Body Odor Changes 

You get the picture on estrogen: This hormone influences pretty much every system in your body, leading to some unexpected and weird perimenopause symptoms, including changes in body odor. Hormonal shifts during the menopause transition can increase sweating, much like they do during puberty. Hot flashes can add to the problem, making your usual body odor seem stronger or different than it used to.

Body odor changes aren't usually a cause for medical concern and are often fairly straightforward to manage, so put away the shame and try some simple fixes.

What helps:

  • Trying a stronger deodorant or clinical-strength antiperspirant
  • Changing out of sweaty clothes and showering after exercise or hot flashes
  • Wearing breathable, moisture-wicking fabrics

26. Fatigue 

Fatigue is a tricky symptom because it has so many potential causes at midlife, from family and work obligations to hormone fluctuations. It may show up in different ways, like feeling drained or having trouble making it through the day. Other menopause symptoms—especially poor sleep and night sweats—can cause fatigue or make it worse.

What helps: 

  • Getting regular exercise, even if it's just a daily walk 
  • Sticking to a consistent sleep schedule and practicing good sleep habits 
  • Limiting caffeine and alcohol, especially later in the day 
  • Quitting smoking or other nicotine products

27. Brain Fog 

Ever walk into a room and completely forget why you went in there? Occasional memory lapses happen to the best of us. But what happens when that forgetfulness starts happening more often? 

Brain fog is one of the most common, albeit unexpected, neurological symptoms of perimenopause. It can make it harder to focus, find the right words, or remember everyday details. As estrogen and progesterone fluctuate, they may affect brain pathways involved in learning and memory. Plus, midlife symptoms like poor sleep, stress, and hot flashes can make brain fog even worse. 

What helps: 

  • Prioritizing good sleep and regular physical activity 
  • Challenging your brain with activities like reading, puzzles, or learning new skills 
  • Managing stress with mindfulness or other relaxation techniques 
  • Talking with a healthcare professional about whether menopause hormone therapy is appropriate for you, if persistent brain fog is accompanied by other menopause symptoms

28. Mood Swings

If you've found yourself snapping over little things or feeling less patient than usual, hormones could be part of the reason. But mood swings during perimenopause don't always look like sadness. They can also show up as sudden or increased irritability, frustration, anger, or even rage, which can catch a lot of women by surprise. 

As estrogen begins a rocky decline, changing hormone levels can affect mood-regulating brain chemicals like serotonin and dopamine. Hormones are only one piece of the puzzle, though. Hot flashes, poor sleep, and everyday stress can make emotional ups and downs feel even more intense.

What helps:

  • Prioritizing restful sleep and regular physical activity
  • Managing stress with mindfulness, therapy, or relaxation techniques
  • Seeking support, like cognitive behavioral therapy (CBT), if you feel persistently irritable or unlike yourself 
  • Talking with a healthcare professional about hormone therapy or other treatments if symptoms affect your daily life

29. Anxiety and Depression 

Let's be clear: Changes to your mental well-being certainly aren't "weird" perimenopause symptoms, but they are symptoms that may surprise you or throw you offguard in midlife. Mood changes are common during perimenopause, but persistent anxiety or depression isn’t something you have to "just live with." 

Perimenopausal women are about 40% more likely to experience depressive symptoms or receive a depression diagnosis than before menopause, and as many as 51% of midlife women report anxiety symptoms such as nervousness, tension, or worry. 

Hormone fluctuations contribute to anxiety, depression, low mood, low motivation, or sadness, and may also make you feel overwhelmed. If symptoms are persistent, severe, or start affecting your daily life, talk with a healthcare professional.

What helps: 

  • Getting regular exercise, like walking, dancing, or swimming 
  • Talking with a mental health professional or trying cognitive behavioral therapy (CBT) 
  • Taking prescription anti-anxiety or antidepressant medications if recommended 
  • Asking a healthcare professional whether hormone therapy may be appropriate

30. Panic Attacks 

Panic-like episodes or panic attacks can happen during the menopause transition and may feel incredibly overwhelming. In one study, nearly 18% of postmenopausal women reported having a panic attack within the previous 6 months.

An episode can cause an intense feeling of fear, sweating, a racing heart, shortness of breath, and chest discomfort that may be mistaken for a heart attack. Hormone fluctuations may contribute, but stress, depression, and other factors can also play a role. 

The good news? Panic disorder can be managed with the right treatment and support.

What helps: 

  • Getting regular exercise and practicing paced breathing
  • Seeking cognitive behavioral therapy (CBT)
  • Talking with a healthcare professional about anti-anxiety medications or antidepressants
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Diagnosis and Testing 

Many of the so-called “weird” perimenopause symptoms we covered can overlap with other health conditions. So there’s no single test––not even popular at-home perimenopause tests––that can confirm what's causing them.

Instead, a healthcare professional, like one of the menopause-trained clinicians at Midi, will usually look at the bigger picture, including your age, menstrual cycle changes, symptoms, and medical history. This can help determine where you are in the menopause transition. 

Hormone testing isn't usually necessary to diagnose menopause, because hormone levels fluctuate so much throughout the transition. But testing may be helpful if your perimenopause  symptoms start earlier than expected (before age 45), are severe or unusual, or could be caused by another condition.

Before your visit, it can help to keep track of:

  • Your period dates and any bleeding changes 
  • Hot flashes, sleep problems, mood changes, or pain
  • Heart palpitations, digestive symptoms, or urinary changes
  • Medications and supplements you take 
  • Possible symptom triggers, such as certain foods, alcohol, caffeine, or stress

Depending on your symptoms, your provider may also recommend tests to rule out other conditions or check for health concerns that become more common during midlife, such as thyroid disorders, iron deficiency or anemia, low vitamin B12 or vitamin D levels, pregnancy (it can still happen in perimenopause), or bone loss.

How to Ease Weird Perimenopause Symptoms

You don't have to suffer through uncomfortable or weird perimenopause symptoms. A healthcare professional can help identify what's causing your symptoms and create a treatment plan that fits your needs.

Depending on what's going on, your care solutions may include:

  • Healthy lifestyle habits: Regular exercise, restful sleep, stress management, and a balanced diet can help improve overall health and ease some menopause symptoms.
  • Hormone therapy: Hormone replacement therapy (HRT, now commonly referred to as menopause hormone therapy, or MHT) is the most effective treatment for hot flashes, night sweats, and vaginal and urinary symptoms.
  • Non-hormonal prescriptions: Non-hormonal medications may help ease hot flashes, vaginal dryness, and other perimenopause symptoms if hormone therapy isn’t a good fit. 
  • Mental health support: Therapy, stress-management techniques, and, in some cases, medication can help if mood changes, anxiety, or depression are taking a toll on your daily life.
  • Pelvic floor therapy: A pelvic floor physical therapist can help reduce pain during sex and improve certain bladder symptoms. 
  • Vitamins and supplements: Some OTC supplements—such as vitamin D, and magnesium—may help ease symptoms like stress, poor sleep, or fatigue. But the evidence is mixed, and product quality varies. A healthcare professional can help you decide whether a supplement is safe and appropriate for your symptoms.
  • Specialist referrals: Depending on your symptoms, you may benefit from seeing a dermatologist, pelvic floor physical therapist, dentist, or another specialist. 
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Key Takeaways 

  • Weird perimenopause symptoms can affect much more than your reproductive system. Hormone changes may contribute to everything from itchy skin and brain fog to heart palpitations, digestive changes, and bladder symptoms. 
  • During perimenopause, fluctuating hormones, especially estrogen, can affect many different body systems, but not every new or unusual symptom is caused by perimenopause. 
  • Tracking your symptoms—including changes in your periods, sleep, mood, hot flashes, and possible triggers—can help you and your healthcare professional identify patterns and rule out other causes. 
  • Many weird perimenopause symptoms can improve with healthy lifestyle habits, targeted treatments, menopause hormone therapy (MHT) when appropriate, or non-hormonal options. 
  • You don't have to figure it out on your own. Seek medical advice from a menopause-trained clinician, like one at Midi. They can help determine what's causing your symptoms and create a personalized treatment plan based on your health history and goals.
How Midi Can Help You

If you’re in perimenopause or menopause and want guidance from clinicians who specialize in women’s midlife health, book a virtual visit with Midi today. 

Hormonal change is at the root of dozens of symptoms women experience in the years before and after their period stops. 

Our trained menopause specialists can help you connect the dots to guide you towards safe, effective solutions.

Whether you need personalized guidance or a prescription routine to tackle symptoms—including brain fog, hot flashes, sleep trouble, mood swings, and weight gain—we’ve got you covered.

EDITORIAL STANDARDS

Midi’s mission is to revolutionize healthcare for women at midlife, wherever they live and whatever their health story. We believe that starts with education, to help all of us understand our always-changing bodies and health needs. Our core values guide everything we do, including standards that ensure the quality and trustworthiness of our content and editorial processes. We’re committed to providing information that is up-to-date, accurate, and relies on evidence-based research and peer-reviewed journals. For more details on our editorial process, see here.